Equipalazone
Disclaimer: This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Equipalazone but is not affiliated with or related to the manufacturer of Equipalazone and the contents of this site are neither sponsored or endorsed by the manufacturer of Equipalazone.
Introduction
1. Equipalazone 1g Oral Paste
2. Equipalazone 1g Oral Powder
3. Equipalazone 200mg/ml Solution for Injection
Presentation
1. Equipalazone 1g Oral Paste
Palatable paste for oral administration, containing per unit dose:
1 g Phenylbutazone
Preservatives:
0.006 g Sodium Methyl Parahydroxybenzoate
0.0015 g Sodium Propyl Parahydroxybenzoate
2. Equipalazone 1g Oral Powder
Free flowing white/cream powder for oral administration, containing 1 g micro-encapsulated Phenylbutazone per sachet.
Preservative: Sodium Paracombin 0.15 % w/w
3. Equipalazone 200mg/ml Solution for Injection
A sterile aqueous solution for injection, containing Phenylbutazone 200 mg/ml.
Preservative: Benzyl Alcohol 1.5 % v/v
Uses
1. Equipalazone 1g Oral Paste
Equipalazone 1 g Oral Paste is indicated in the treatment of musculoskeletal disorders in horses and ponies where the anti-inflammatory and analgesic properties of Phenylbutazone can offer relief, for example, in lameness associated with osteoarthritic conditions, acute and chronic laminitis, bursitis and carpitis.
2. Equipalazone 1g Oral Powder
Equipalazone 1 g Oral Powder is indicated in the treatment of musculoskeletal disorders in horses and ponies where the anti-inflammatory and analgesic properties of Phenylbutazone can offer relief, for example, in lameness associated with osteoarthritic conditions, acute and chronic laminitis, bursitis and carpitis, and in the reduction of post-surgical soft tissue reaction.
3. Equipalazone 200mg/ml Solution for Injection
Equipalazone 200 mg/ml Solution for Injection is indicated in the treatment of musculoskeletal disorders in horses and ponies where the anti-inflammatory and analgesic properties of Phenylbutazone can offer relief against inflammation, pain and lameness.
Dosage & administration
1. Equipalazone 1g Oral Paste
Each marked division (2 turns of the ring) is equivalent to 1 unit dose (i.e. 1 g Phenylbutazone).
Horses: 450 kg (1000 lbs) bodyweight:
2 unit doses twice on day one (equivalent to 8.8 mg/kg/day), 1 unit dose twice daily for four days (4.4 mg/kg/day) followed by 1 unit dose daily or on alternate days (2.2 mg/kg/day), sufficient to keep the animal comfortable.
Ponies: 225 kg (500 lbs) bodyweight:
1 unit dose (4.4 mg/kg) on alternate days.
Remove cap from nozzle, turn ring to required dosage and express as near to the back of the tongue as possible. Replace cap after use.
Adjust dose according to bodyweight.
Discontinue treatment if no response is evident after four to five days treatment.
2. Equipalazone 1g Oral Powder
Dependent on individual response, but as a guide:
Horses: 450 kg (1000 lb) bodyweight:
Two sachets to be administered twice on day one (equivalent to 8.8 mg/kg/day) followed by one sachet twice daily for four days (4.4 mg/kg/day), then one sachet daily or on alternate days sufficient to keep the horse comfortable (2.2 mg/kg/day).
Ponies: 225 kg (500 lb) bodyweight:
One sachet (4.4 mg/kg/day) on alternate days.
Adjust dose according to bodyweight.
Discontinue treatment if no response is evident after four to five days treatment.
For ease of administration, Equipalazone 1 g Oral Powder may be mixed with a small quantity of bran or oats.
3. Equipalazone 200mg/ml Solution for Injection
Horses: 450 kg (1000 lb) bodyweight:
Maximum 10 ml (4.4 mg Phenylbutazone/kg).
Ponies: 225 kg (500 lb) bodyweight:
Maximum 5 ml (4.4 mg Phenylbutazone/kg)
Equipalazone 200 mg/ml Solution for Injection should be administered by slow intravenous injection as a single dose, which may be followed if necessary by oral Phenylbutazone therapy commencing 24 hours after the injection.
In acute cases and in hospitalised animals, Equipalazone 200 mg/ml Solution for Injection may be administered once daily for not more than five consecutive days.
Price comparison
Contra-indications, warnings, etc.
1. Equipalazone 1g Oral Paste, 2. Equipalazone 1g Oral Powder & 3. Equipalazone 200mg/ml Solution for Injection
Treated horses may never be slaughtered for human consumption.
The therapeutic index of Phenylbutazone is low.
Do not exceed the stated dose or the duration of treatment.
Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastrointestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia or hypersensitivity to the product.
Do not administer other NSAIDs concurrently or within 24 hours of each other.
Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs to produce an increase in non-bound pharmacologically active concentrations, which can lead to toxic effects.
Use in animals less than six weeks of age, or in aged animals, may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal as there is a risk of increased renal toxicity.
Concurrent administration of potentially nephrotoxic drugs should be avoided.
It is preferable that NSAIDs which inhibit prostaglandin synthesis are not administered to animals undergoing general anaesthesia until fully recovered.
Use during pregnancy should be avoided whenever possible, particularly during the first trimester.
Operator warnings: The product should be handled with care at all times to reduce the risk of accidental ingestion or skin contact. If accidental skin or eye contact occurs, the site should be washed immediately with water. If the product is ingested, seek medical advice immediately and show the product packaging.
Advice to doctors: gastric lavage (emesis in children) should be performed urgently. Charcoal haemoperfusion has also been shown to be beneficial. Treatment should then be administered symptomatically.
General precautions: For animal treatment only.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infections, appropriate concurrent antimicrobial therapy should be instigated.
Withdrawal period: Do not use in animals intended for human consumption.
Pharmaceutical precautions
1. Equipalazone 1g Oral Paste & 2. Equipalazone 1g Oral Powder
Do not store above 25°C. Keep out of the reach and sight of children.
Any contents remaining later than 28 days after the first opening should be discarded.
Disposal: Dispose of any unused product and empty containers in accordance with guidance from your national waste regulation authority.
3. Equipalazone 200mg/ml Solution for Injection
Store between +2 and +8°C. Protect from light. Keep out of the reach and sight of children.
Once the vial is broached, following withdrawal of the first dose use the product within 28 days. Discard unused material.
Disposal: Dispose of any unused product and empty containers in accordance with guidance from your national waste regulation authority.
Packaging quantities
1. Equipalazone 1g Oral Paste
Dial-a-dose syringes containing 6 unit doses.
2. Equipalazone 1g Oral Powder
Boxes of 32 and 100 sachets.
3. Equipalazone 200mg/ml Solution for Injection
Multidose vials of 50 ml.
Further information
1. Equipalazone 1g Oral Paste, 2. Equipalazone 1g Oral Powder & 3. Equipalazone 200mg/ml Solution for Injection
The clinical effect of Phenylbutazone can be evident for at least 3 days following cessation of administration. This should be borne in mind when examining the horse for soundness.
Some authorities (including the Jockey Club) regard Phenylbutazone as a "prohibited substance" under the rules of competition. Therefore, use of this product in a competition horse should be in accordance with the recommendations/advice of the relevant competition authorities.
To be supplied only on veterinary prescription.
Veterinary medicinal product authorised for use in UK and Ireland.
Disclaimer
This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Equipalazone but is not affiliated with or related to the manufacturer of Equipalazone and the contents of this site are neither sponsored or endorsed by the manufacturer of Equipalazone.
